Assay Detail
Binding
CHEMBL767089
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Inhibition of guinea pig ventricular Phosphodiesterase 4
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.82 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414613 | — | — | 1 | 7.25 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.50 |
| CHEMBL285457 | — | — | 1 | 6.22 |
| CHEMBL30894 | — | — | 1 | 6.10 |
| CHEMBL29546 | — | — | 1 | 6.05 |
| CHEMBL31725 | — | — | 1 | 5.96 |
| CHEMBL283179 | — | — | 1 | 5.89 |
| CHEMBL33501 | — | — | 1 | 5.70 |
| CHEMBL31005 | — | — | 1 | 5.51 |
| CHEMBL31046 | — | — | 1 | 5.13 |
| CHEMBL30593 | — | — | 1 | 4.96 |
| CHEMBL281045 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414613 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL285457 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL30894 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL29546 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL31725 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL283179 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL33501 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL31005 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL31046 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL30593 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL281045 | — | IC50 | = | 31000.0 | nM | 4.51 |