Assay Detail
Binding
CHEMBL767091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against (PDE IV) phosphodiesterase IV in guinea pig articular tissue
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.79 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31530 | — | — | 1 | 6.40 |
| CHEMBL30619 | — | — | 1 | 6.22 |
| CHEMBL31063 | — | — | 1 | 6.22 |
| CHEMBL30406 | — | — | 1 | 6.22 |
| CHEMBL30733 | — | — | 1 | 6.22 |
| CHEMBL434590 | — | — | 1 | 6.16 |
| CHEMBL288545 | — | — | 1 | 6.10 |
| CHEMBL281244 | — | — | 1 | 6.08 |
| CHEMBL30379 | — | — | 1 | 6.05 |
| CHEMBL288547 | — | — | 1 | 6.00 |
| CHEMBL31439 | — | — | 1 | 6.00 |
| CHEMBL30407 | — | — | 1 | 6.00 |
| CHEMBL31035 | — | — | 1 | 5.96 |
| CHEMBL30966 | — | — | 1 | 5.96 |
| CHEMBL31390 | — | — | 1 | 5.89 |
| CHEMBL28562 | — | — | 1 | 5.85 |
| CHEMBL30941 | — | — | 1 | 5.82 |
| CHEMBL31715 | — | — | 1 | 5.82 |
| CHEMBL31157 | — | — | 1 | 5.82 |
| CHEMBL32673 | — | — | 1 | 5.64 |
| CHEMBL30671 | — | — | 1 | 5.64 |
| CHEMBL31305 | — | — | 1 | 5.60 |
| CHEMBL31743 | — | — | 1 | 5.57 |
| CHEMBL435363 | — | — | 1 | 5.52 |
| CHEMBL31773 | — | — | 1 | 5.40 |
| CHEMBL31795 | — | — | 1 | 5.40 |
| CHEMBL30879 | — | — | 1 | 5.33 |
| CHEMBL31877 | — | — | 1 | 4.85 |
| CHEMBL30567 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31530 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL30619 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL31063 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL30406 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL30733 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL434590 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL288545 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL281244 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL30379 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL288547 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL31439 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL30407 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL31035 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL30966 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL31390 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL28562 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL30941 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL31715 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL31157 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL32673 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL30671 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL31305 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL31743 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL435363 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL31773 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL31795 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL30879 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL31877 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL30567 | — | IC50 | = | 65000.0 | nM | 4.19 |