Assay Detail
Binding
CHEMBL767095
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Displacement of [3H]rolipram from mouse brain homogenates
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.31 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282934 | — | — | 1 | 8.52 |
| CHEMBL278386 | — | — | 1 | 8.52 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.40 |
| CHEMBL280185 | — | — | 1 | 8.30 |
| CHEMBL21964 | — | — | 1 | 8.05 |
| CHEMBL281781 | — | — | 1 | 7.82 |
| CHEMBL21463 | — | — | 1 | 7.82 |
| CHEMBL21839 | — | — | 1 | 6.96 |
| CHEMBL21305 | — | — | 1 | 6.89 |
| CHEMBL21327 | — | — | 1 | 6.89 |
| CHEMBL422219 | — | — | 1 | 6.49 |
| CHEMBL280729 | — | — | 1 | 6.18 |
| CHEMBL22461 | — | — | 1 | 5.78 |
| CHEMBL22898 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282934 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL278386 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL280185 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL21964 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL281781 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL21463 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL21839 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL21305 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL21327 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL422219 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL280729 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL22461 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL22898 | — | IC50 | = | 1900.0 | nM | 5.72 |