Assay Detail
Binding
CHEMBL767096
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Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.05 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.40 |
| CHEMBL60985 | — | — | 1 | 5.50 |
| CHEMBL291838 | — | — | 1 | 5.34 |
| CHEMBL61884 | — | — | 1 | 4.30 |
| CHEMBL60007 | — | — | 1 | 4.24 |
| CHEMBL294606 | — | — | 1 | 4.24 |
| CHEMBL59408 | — | — | 1 | 4.21 |
| CHEMBL60060 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL60985 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL291838 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL61884 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL60007 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL294606 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL59408 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL60060 | — | IC50 | = | 66000.0 | nM | 4.18 |