Assay Detail
Binding
CHEMBL767152
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Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.79 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418207 | — | — | 1 | 7.58 |
| CHEMBL30108 | — | — | 1 | 7.52 |
| CHEMBL29838 | — | — | 1 | 7.10 |
| CHEMBL286067 | — | — | 1 | 6.92 |
| CHEMBL286068 | — | — | 1 | 6.82 |
| CHEMBL26200 | — | — | 1 | 6.82 |
| CHEMBL29246 | — | — | 1 | 6.70 |
| CHEMBL282164 | — | — | 1 | 6.39 |
| CHEMBL30130 | — | — | 1 | 6.34 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | — | 1 | 6.10 |
| CHEMBL27531 | — | — | 1 | 5.70 |
| CHEMBL25853 | — | — | 1 | 5.66 |
| CHEMBL281320 | — | — | 1 | 5.48 |
| CHEMBL413539 | — | — | 1 | 5.34 |
| CHEMBL29987 | — | — | 1 | 5.28 |
| CHEMBL442099 | — | — | 1 | 5.19 |
| CHEMBL25900 | — | — | 1 | 5.13 |
| CHEMBL30198 | — | — | 1 | 4.80 |
| CHEMBL416760 | — | — | 1 | 4.70 |
| CHEMBL27543 | — | — | 1 | 4.58 |
| CHEMBL29707 | — | — | 1 | 4.55 |
| CHEMBL416027 | — | — | 1 | 4.28 |
| CHEMBL29497 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418207 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL30108 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL29838 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL286067 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL286068 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL26200 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL29246 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL282164 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL30130 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL27531 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL25853 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL281320 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL413539 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL29987 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL442099 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL25900 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL30198 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL416760 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL27543 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL29707 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL416027 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL29497 | — | IC50 | = | 67000.0 | nM | 4.17 |