Assay Detail
Binding
CHEMBL767201
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In vitro inhibition of Plasmodium falciparum Glutathione Reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum FcB1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.80 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135287 | — | — | 1 | 6.30 |
| CHEMBL135536 | — | — | 1 | 5.89 |
| CHEMBL135504 | — | — | 1 | 5.60 |
| CHEMBL134615 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135287 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL135536 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL135504 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL134615 | — | IC50 | = | 4000.0 | nM | 5.40 |