Assay Detail
Functional
CHEMBL767230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 76 | 6.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431799 | — | — | 1 | 8.30 |
| CHEMBL91368 | — | — | 1 | 8.30 |
| CHEMBL90804 | — | — | 1 | 8.22 |
| CHEMBL90237 | — | — | 1 | 8.10 |
| CHEMBL88444 | — | — | 1 | 7.70 |
| CHEMBL91527 | — | — | 1 | 7.70 |
| CHEMBL90195 | — | — | 1 | 7.70 |
| CHEMBL88218 | — | — | 1 | 7.40 |
| CHEMBL92363 | — | — | 1 | 7.30 |
| CHEMBL91478 | — | — | 1 | 7.26 |
| CHEMBL88955 | — | — | 1 | 7.22 |
| CHEMBL88136 | — | — | 1 | 7.18 |
| CHEMBL91422 | — | — | 1 | 7.16 |
| CHEMBL91837 | — | — | 1 | 7.05 |
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 7.00 |
| CHEMBL90414 | — | — | 1 | 6.96 |
| CHEMBL92264 | — | — | 1 | 6.92 |
| CHEMBL88764 | — | — | 1 | 6.85 |
| CHEMBL91044 | — | — | 1 | 6.82 |
| CHEMBL88245 | — | — | 1 | 6.75 |
| CHEMBL91356 | — | — | 1 | 6.75 |
| CHEMBL92269 | — | — | 1 | 6.75 |
| CHEMBL88708 | — | — | 1 | 6.68 |
| CHEMBL328149 | — | — | 1 | 6.68 |
| CHEMBL89679 | — | — | 1 | 6.60 |
| CHEMBL314763 | — | — | 1 | 6.58 |
| CHEMBL89660 | — | — | 1 | 6.55 |
| CHEMBL327374 | — | — | 1 | 6.48 |
| CHEMBL88877 | — | — | 1 | 6.44 |
| CHEMBL91570 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431799 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL91368 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL90804 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL90237 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL88444 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL91527 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL90195 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL88218 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL92363 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL91478 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL88955 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL88136 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL91422 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL91837 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL69139 | LIXAZINONE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL90414 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL92264 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL88764 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL91044 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL88245 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL91356 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL92269 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL88708 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL328149 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL89679 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL314763 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL89660 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL327374 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL88877 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL91570 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL90677 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL93688 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL88583 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL91259 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL91204 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL420980 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL91127 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL88730 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL420618 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL90881 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL423864 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL330677 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL89876 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL88108 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL91843 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL88799 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL92158 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL313463 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL760 | ANAGRELIDE | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL88707 | — | EC50 | = | 1070.0 | nM | 5.97 |