Assay Detail
Functional
CHEMBL767352
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In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.29 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479432 | FEBRIFUGINE | — | 1 | 8.92 |
| CHEMBL105789 | ISOFEBRIFUGINE | — | 1 | 8.74 |
| CHEMBL110619 | — | — | 1 | 8.52 |
| CHEMBL107040 | — | — | 1 | 8.38 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479432 | FEBRIFUGINE | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL105789 | ISOFEBRIFUGINE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL110619 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL107040 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 130.0 | nM | 6.89 |