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Assay Detail

CHEMBL767436

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of protein kinase C (PKC)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2093867)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.
Gingrich DE, Hudkins RL.
Bioorg Med Chem Lett (2002) 12 : 2829 -2831
PubMed 12270156 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.77 6.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94678 1 6.94
CHEMBL281948 K-252A 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94678 IC50 = 114.0 nM 6.94
CHEMBL281948 K-252A IC50 = 250.0 nM 6.60