Assay Detail
Binding
CHEMBL767445
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Inhibition of protein kinase C
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Preparation of synthons for the synthesis of protein kinase C inhibitors from rebeccamycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.58 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.57 |
| CHEMBL574737 | UCN-01 | 2.0 | 2 | 8.39 |
| CHEMBL281948 | K-252A | — | 1 | 7.48 |
| CHEMBL140600 | — | — | 1 | 7.42 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.61 |
| CHEMBL423731 | — | — | 1 | 5.52 |
| CHEMBL127277 | — | — | 1 | 4.66 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 4.35 |
| CHEMBL139517 | — | — | 1 | - |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL574737 | UCN-01 | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL281948 | K-252A | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL140600 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL574737 | UCN-01 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL423731 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL127277 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL139517 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL370100 | REBECCAMYCIN | IC50 | > | 100000.0 | nM | - |