Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL767468

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of protein kinase C (PKC) from rat brain homogenate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2094266)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Mixed lineage kinase activity of indolocarbazole analogues.
Murakata C, Kaneko M, Gessner G, Angeles TS, Ator MA, O'Kane TM, McKenna BA, Thomas BA, Mathiasen JR, Saporito MS, Bozyczko-Coyne D, Hudkins RL.
Bioorg Med Chem Lett (2002) 12 : 147 -150
PubMed 11755341 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.47 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289772 1 8.52
CHEMBL36891 1 6.65
CHEMBL288229 1 6.40
CHEMBL288817 1 6.35
CHEMBL288816 1 6.01
CHEMBL38338 1 5.80
CHEMBL277817 1 5.58
CHEMBL37529 1 -
CHEMBL288818 1 -
CHEMBL29709 1 -
CHEMBL290352 CEP-1347 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289772 IC50 = 3.0 nM 8.52
CHEMBL36891 IC50 = 222.0 nM 6.65
CHEMBL288229 IC50 = 400.0 nM 6.40
CHEMBL288817 IC50 = 450.0 nM 6.35
CHEMBL288816 IC50 = 980.0 nM 6.01
CHEMBL38338 IC50 = 1600.0 nM 5.80
CHEMBL277817 IC50 = 2600.0 nM 5.58
CHEMBL37529 IC50 > 10000.0 nM -
CHEMBL288818 IC50 > 10000.0 nM -
CHEMBL29709 IC50 > 7600.0 nM -
CHEMBL290352 CEP-1347 IC50 > 10000.0 nM -