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Assay Detail

CHEMBL767474

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Binding
Tested for inhibition of protein kinase C from rat brain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2094266)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties
Kleinschroth J, Hartenstein J, Rudolph C, Schachtele C
Bioorg Med Chem Lett (1995) 5 : 55 -60
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.65 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL345593 1 8.70
CHEMBL157822 1 8.40
CHEMBL156433 1 8.30
CHEMBL348902 1 8.22
CHEMBL348563 1 8.05
CHEMBL388978 STAUROSPORINE 1 8.05
CHEMBL347154 1 7.80
CHEMBL157528 1 7.80
CHEMBL302449 GO-6976 1 7.70
CHEMBL156172 1 7.68
CHEMBL346038 1 7.52
CHEMBL155929 1 7.50
CHEMBL348177 1 7.42
CHEMBL157892 1 7.35
CHEMBL346467 1 7.25
CHEMBL345639 1 7.07
CHEMBL154245 1 6.64
CHEMBL157967 1 6.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL345593 IC50 = 2.0 nM 8.70
CHEMBL157822 IC50 = 4.0 nM 8.40
CHEMBL156433 IC50 = 5.0 nM 8.30
CHEMBL348902 IC50 = 6.0 nM 8.22
CHEMBL348563 IC50 = 9.0 nM 8.05
CHEMBL388978 STAUROSPORINE IC50 = 9.0 nM 8.05
CHEMBL347154 IC50 = 16.0 nM 7.80
CHEMBL157528 IC50 = 16.0 nM 7.80
CHEMBL302449 GO-6976 IC50 = 20.0 nM 7.70
CHEMBL156172 IC50 = 21.0 nM 7.68
CHEMBL346038 IC50 = 30.0 nM 7.52
CHEMBL155929 IC50 = 32.0 nM 7.50
CHEMBL348177 IC50 = 38.0 nM 7.42
CHEMBL157892 IC50 = 45.0 nM 7.35
CHEMBL346467 IC50 = 56.0 nM 7.25
CHEMBL345639 IC50 = 86.0 nM 7.07
CHEMBL154245 IC50 = 230.0 nM 6.64
CHEMBL157967 IC50 = 550.0 nM 6.26