Assay Detail
Binding
CHEMBL767751
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In vitro inhibitory activity against canine prostaglandin G/H synthase 1.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Prostaglandin G/H synthase 1 (CHEMBL4133) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.25 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176265 | — | — | 1 | 7.30 |
| CHEMBL177244 | — | — | 1 | 6.70 |
| CHEMBL175485 | — | — | 1 | 6.48 |
| CHEMBL176983 | — | — | 1 | 6.08 |
| CHEMBL366726 | — | — | 1 | 6.05 |
| CHEMBL177397 | — | — | 1 | 6.00 |
| CHEMBL368724 | — | — | 1 | 5.82 |
| CHEMBL367123 | — | — | 1 | 5.72 |
| CHEMBL174982 | — | — | 1 | 5.70 |
| CHEMBL360705 | — | — | 1 | 5.55 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.25 |
| CHEMBL369315 | — | — | 1 | 5.10 |
| CHEMBL367550 | — | — | 1 | 5.04 |
| CHEMBL367785 | — | — | 1 | 5.00 |
| CHEMBL174724 | — | — | 1 | 5.00 |
| CHEMBL355812 | — | — | 1 | 4.92 |
| CHEMBL173770 | — | — | 1 | 4.85 |
| CHEMBL176642 | — | — | 1 | 4.71 |
| CHEMBL174860 | — | — | 1 | 4.68 |
| CHEMBL28636 | DERACOXIB | 2.0 | 1 | 4.64 |
| CHEMBL176934 | — | — | 1 | 4.62 |
| CHEMBL366992 | — | — | 1 | 4.55 |
| CHEMBL174586 | — | — | 1 | 4.54 |
| CHEMBL367617 | — | — | 1 | 4.44 |
| CHEMBL176387 | — | — | 1 | 4.39 |
| CHEMBL368173 | — | — | 1 | 4.32 |
| CHEMBL174219 | — | — | 1 | 4.32 |
| CHEMBL443302 | — | — | 1 | - |
| CHEMBL175340 | — | — | 1 | - |
| CHEMBL367179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176265 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL177244 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL175485 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL176983 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL366726 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL177397 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL368724 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL367123 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL174982 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL360705 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL118 | CELECOXIB | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL369315 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL367550 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL367785 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL174724 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL355812 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL173770 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL176642 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL174860 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL28636 | DERACOXIB | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL176934 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL366992 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL174586 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL367617 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL176387 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL174219 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL368173 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL443302 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL175340 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL367179 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL175826 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177649 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL366677 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL366517 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL176677 | — | IC50 | > | 50000.0 | nM | - |