Assay Detail
Binding
CHEMBL767761
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Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.74 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.70 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.70 |
| CHEMBL18251 | — | — | 1 | 7.16 |
| CHEMBL18498 | — | — | 1 | 7.16 |
| CHEMBL19056 | — | — | 1 | 6.96 |
| CHEMBL275664 | — | — | 1 | 6.96 |
| CHEMBL279268 | — | — | 1 | 6.96 |
| CHEMBL273815 | — | — | 1 | 6.85 |
| CHEMBL18316 | — | — | 1 | 6.80 |
| CHEMBL280009 | — | — | 1 | 6.70 |
| CHEMBL273340 | — | — | 1 | 6.60 |
| CHEMBL277118 | — | — | 1 | 6.51 |
| CHEMBL18790 | — | — | 1 | 6.50 |
| CHEMBL18040 | — | — | 1 | 6.42 |
| CHEMBL18867 | — | — | 1 | 6.39 |
| CHEMBL18312 | — | — | 1 | 6.35 |
| CHEMBL416363 | — | — | 1 | 6.26 |
| CHEMBL277519 | — | — | 1 | 6.19 |
| CHEMBL18254 | — | — | 1 | 5.92 |
| CHEMBL275650 | — | — | 1 | 5.72 |
| CHEMBL18377 | — | — | 1 | - |
| CHEMBL18796 | — | — | 1 | - |
| CHEMBL278738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL18251 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL18498 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL19056 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL275664 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL279268 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL273815 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL18316 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL280009 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL273340 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL277118 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL18790 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL18040 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL18867 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL18312 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL416363 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL277519 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL18254 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL275650 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL18377 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL18796 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL278738 | — | IC50 | > | 5000.0 | nM | - |