Assay Detail
Binding
CHEMBL767811
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Binding affinity was determined against prostanoid EP3 receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.02 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413509 | — | — | 1 | 8.10 |
| CHEMBL42027 | — | — | 1 | 5.52 |
| CHEMBL45418 | — | — | 1 | 5.31 |
| CHEMBL440474 | — | — | 1 | 4.92 |
| CHEMBL291182 | — | — | 1 | 4.92 |
| CHEMBL45008 | — | — | 1 | 4.89 |
| CHEMBL42129 | — | — | 1 | 4.80 |
| CHEMBL280223 | — | — | 1 | 4.70 |
| CHEMBL298026 | — | — | 1 | 4.42 |
| CHEMBL46395 | — | — | 1 | 4.42 |
| CHEMBL416262 | — | — | 1 | 4.25 |
| CHEMBL14359 | — | — | 1 | 4.00 |
| CHEMBL297578 | — | — | 1 | - |
| CHEMBL296715 | — | — | 1 | - |
| CHEMBL288978 | — | — | 1 | - |
| CHEMBL417171 | — | — | 1 | - |
| CHEMBL46671 | — | — | 1 | - |
| CHEMBL444574 | — | — | 1 | - |
| CHEMBL47138 | — | — | 1 | - |
| CHEMBL47018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413509 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL42027 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL45418 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL440474 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL291182 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL45008 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL42129 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL280223 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL298026 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL46395 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL416262 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL14359 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL297578 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL296715 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL288978 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL417171 | — | Ki | = | 131000.0 | nM | - |
| CHEMBL46671 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL444574 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL47138 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL47018 | — | Ki | > | 100000.0 | nM | - |