Assay Detail
Functional
CHEMBL767839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compound
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.07 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280055 | — | — | 1 | 8.15 |
| CHEMBL17815 | — | — | 1 | 7.96 |
| CHEMBL18394 | — | — | 1 | 7.92 |
| CHEMBL18946 | — | — | 1 | 7.89 |
| CHEMBL18989 | — | — | 1 | 7.70 |
| CHEMBL278034 | — | — | 1 | 7.70 |
| CHEMBL18694 | — | — | 1 | 7.58 |
| CHEMBL18820 | — | — | 1 | 7.52 |
| CHEMBL18050 | — | — | 1 | 7.51 |
| CHEMBL18250 | — | — | 1 | 7.34 |
| CHEMBL18376 | — | — | 1 | 7.12 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 7.07 |
| CHEMBL278507 | — | — | 1 | 7.00 |
| CHEMBL18559 | — | — | 1 | 6.98 |
| CHEMBL18536 | — | — | 1 | 6.54 |
| CHEMBL280281 | — | — | 1 | 6.42 |
| CHEMBL18632 | — | — | 1 | 6.24 |
| CHEMBL280304 | — | — | 1 | 6.07 |
| CHEMBL274233 | — | — | 1 | 5.67 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280055 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL17815 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL18394 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL18946 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL18989 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL278034 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL18694 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL18820 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL18050 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL18250 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL18376 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL278507 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL18559 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL18536 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL280281 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL18632 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL280304 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL274233 | — | IC50 | = | 2134.0 | nM | 5.67 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 9200.0 | nM | 5.04 |