Assay Detail
Functional
CHEMBL767963
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In vitro inhibition of Plasmodium falciparum K1 (S108N + C59R) culture
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.55 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278847 | — | — | 1 | 9.22 |
| CHEMBL29773 | — | — | 1 | 8.43 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278847 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL29773 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 10.2 | nM | 7.99 |