Assay Detail
Binding
CHEMBL767973
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Inhibition of crude canine cardiac c-AMP phosphodiesterase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 5. Fragments from the heterocycle-phenyl-imidazole pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.69 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17125 | PELRINONE | 2.0 | 1 | 5.40 |
| CHEMBL429931 | — | — | 1 | 5.40 |
| CHEMBL17423 | VESNARINONE | 2.0 | 1 | 4.50 |
| CHEMBL428866 | — | — | 1 | 4.43 |
| CHEMBL16910 | — | — | 1 | 4.27 |
| CHEMBL17516 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17125 | PELRINONE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL429931 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL17423 | VESNARINONE | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL428866 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL16910 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL17516 | — | IC50 | = | 71000.0 | nM | 4.15 |