Assay Detail
Binding
CHEMBL767976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase 3 from guinea pig cardiac tissue at 1E-7-1E-4M or 1.0E-6 to 1E-3 M
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119237 | — | — | 1 | 7.00 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | — | 1 | 6.82 |
| CHEMBL440593 | CI-930 | — | 1 | 6.22 |
| CHEMBL333083 | — | — | 1 | 5.96 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.60 |
| CHEMBL333598 | — | — | 1 | 5.55 |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | 5.10 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | 4.30 |
| CHEMBL117783 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119237 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL282765 | TETRAHYDROBENXIMIDAZOLE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL440593 | CI-930 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL333083 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL189 | MILRINONE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL333598 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL12831 | IMAZODAN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL117783 | — | IC50 | = | 53000.0 | nM | 4.28 |