Assay Detail
Binding
CHEMBL767981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Protein Kinase A (PKA)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.97 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48665 | — | — | 1 | 6.58 |
| CHEMBL146847 | — | — | 1 | 6.03 |
| CHEMBL149313 | — | — | 1 | 5.89 |
| CHEMBL48546 | — | — | 1 | 5.37 |
| CHEMBL48988 | — | — | 1 | - |
| CHEMBL358264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48665 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL146847 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL149313 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL48546 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL48988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL358264 | — | IC50 | > | 10000.0 | nM | - |