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Assay Detail

CHEMBL767984

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Binding
Inhibition of Protein Kinase A (PKA).
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
Pereira ER, Belin L, Sancelme M, Prudhomme M, Ollier M, Rapp M, Sevère D, Riou JF, Fabbro D, Meyer T.
J Med Chem (1996) 39 : 4471 -4477
PubMed 8893841 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.40 4.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL16958 STAUROSPORINONE 1 4.59
CHEMBL127277 1 4.47
CHEMBL140891 1 4.38
CHEMBL138041 1 4.35
CHEMBL268368 STAUROSPORINE AGLYCON 1 4.22
CHEMBL139517 1 -
CHEMBL422107 1 -
CHEMBL3350557 1 -
CHEMBL370100 REBECCAMYCIN 1 -
CHEMBL335822 1 -
CHEMBL343788 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL16958 STAUROSPORINONE IC50 = 25700.0 nM 4.59
CHEMBL127277 IC50 = 34000.0 nM 4.47
CHEMBL140891 IC50 = 41500.0 nM 4.38
CHEMBL138041 IC50 = 44600.0 nM 4.35
CHEMBL268368 STAUROSPORINE AGLYCON IC50 = 60000.0 nM 4.22
CHEMBL139517 IC50 > 100000.0 nM -
CHEMBL422107 IC50 > 100000.0 nM -
CHEMBL3350557 IC50 > 100000.0 nM -
CHEMBL370100 REBECCAMYCIN IC50 > 100000.0 nM -
CHEMBL335822 IC50 > 100000.0 nM -
CHEMBL343788 IC50 > 100000.0 nM -