Assay Detail
Binding
CHEMBL767989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclic AMP dependent protein kinase A (PKA)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.55 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538718 | — | — | 1 | 5.55 |
| CHEMBL26501 | RO-320432 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538718 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL26501 | RO-320432 | IC50 | = | 223375.0 | nM | - |