Assay Detail
Binding
CHEMBL768097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Protein kinase C beta 2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.43 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | — | 1 | 8.22 |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 8.22 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | — | 1 | 7.34 |
| CHEMBL340776 | — | — | 1 | 5.93 |
| CHEMBL337642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL91829 | RUBOXISTAURIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL340776 | — | IC50 | = | 1163.0 | nM | 5.93 |
| CHEMBL337642 | — | IC50 | > | 10000.0 | nM | - |