Assay Detail
Binding
CHEMBL768120
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against HIV protease
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Nonsymmetrically substituted cyclic urea HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 9.94 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85653 | — | — | 1 | 10.96 |
| CHEMBL133292 | — | — | 1 | 10.92 |
| CHEMBL133291 | — | — | 1 | 10.80 |
| CHEMBL262642 | — | — | 1 | 10.74 |
| CHEMBL336730 | — | — | 1 | 10.64 |
| CHEMBL131268 | — | — | 1 | 10.62 |
| CHEMBL131508 | — | — | 1 | 10.42 |
| CHEMBL81383 | — | — | 1 | 10.37 |
| CHEMBL335935 | — | — | 1 | 10.33 |
| CHEMBL335424 | — | — | 1 | 10.28 |
| CHEMBL336885 | — | — | 1 | 10.16 |
| CHEMBL434612 | — | — | 1 | 10.12 |
| CHEMBL434427 | — | — | 1 | 10.02 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 9.77 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.60 |
| CHEMBL223824 | MOZENAVIR | 2.0 | 1 | 9.51 |
| CHEMBL21145 | DMP-323 | — | 1 | 9.49 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.43 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.43 |
| CHEMBL335651 | — | — | 1 | 9.39 |
| CHEMBL339147 | — | — | 1 | 9.15 |
| CHEMBL436577 | — | — | 1 | 9.07 |
| CHEMBL132175 | — | — | 1 | 8.72 |
| CHEMBL132231 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85653 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL133292 | — | Ki | = | 0.012 | nM | 10.92 |
| CHEMBL133291 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL262642 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL336730 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL131268 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL131508 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL81383 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL335935 | — | Ki | = | 0.047 | nM | 10.33 |
| CHEMBL335424 | — | Ki | = | 0.053 | nM | 10.28 |
| CHEMBL336885 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL434612 | — | Ki | = | 0.075 | nM | 10.12 |
| CHEMBL434427 | — | Ki | = | 0.096 | nM | 10.02 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL223824 | MOZENAVIR | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL21145 | DMP-323 | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL335651 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL339147 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL436577 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL132175 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL132231 | — | Ki | = | 2.511 | nM | 8.60 |