Assay Detail
Binding
CHEMBL768123
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Binding affinity against HIV-1 aspartic proteinase was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.81 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109500 | — | — | 1 | 9.62 |
| CHEMBL301728 | ACETYLPEPSTATIN | — | 1 | 7.70 |
| CHEMBL48996 | — | — | 1 | 6.11 |
| CHEMBL2062130 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109500 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL301728 | ACETYLPEPSTATIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL48996 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL2062130 | — | Ki | < | 1.0 | nM | - |