Assay Detail
Binding
CHEMBL768140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular design of novel PGI2 agonists without PG skeleton. III
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11211 | — | — | 1 | 8.00 |
| CHEMBL10836 | — | — | 1 | 7.70 |
| CHEMBL11291 | — | — | 1 | 6.68 |
| CHEMBL266622 | — | — | 1 | 6.34 |
| CHEMBL417069 | — | — | 1 | 5.62 |
| CHEMBL11571 | — | — | 1 | 5.38 |
| CHEMBL274393 | — | — | 1 | 5.10 |
| CHEMBL11394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11211 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL10836 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL11291 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL266622 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL417069 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL11571 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL274393 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL11394 | — | IC50 | > | 10000.0 | nM | - |