Assay Detail
Binding
CHEMBL768151
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Inhibitory concentration against Protein phosphatase 2A (25 nM) isolated from bovine myocardial tissue
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (CHEMBL4703) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.34 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280487 | OKADAIC ACID | — | 1 | 8.15 |
| CHEMBL2368224 | — | — | 1 | 6.52 |
| CHEMBL158922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280487 | OKADAIC ACID | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2368224 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL158922 | — | IC50 | > | 1000000.0 | nM | - |