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Assay Detail

CHEMBL768152

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against protein phosphatase 2A from human red blood cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.
Hart ME, Chamberlin AR, Walkom C, Sakoff JA, McCluskey A.
Bioorg Med Chem Lett (2004) 14 : 1969 -1973
PubMed 15050639 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.26 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL48449 CANTHARIDIN 4.0 1 6.22
CHEMBL8327 DEMETHYL-CANTHARIDIN 1 6.02
CHEMBL368311 1 5.50
CHEMBL175630 1 5.16
CHEMBL177853 1 5.11
CHEMBL425851 1 5.04
CHEMBL175996 1 5.04
CHEMBL175576 1 4.92
CHEMBL6951 1 4.89
CHEMBL367750 1 4.68
CHEMBL368606 1 -
CHEMBL369464 1 -
CHEMBL368167 1 -
CHEMBL176328 1 -
CHEMBL369584 1 -
CHEMBL174701 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL48449 CANTHARIDIN IC50 = 600.0 nM 6.22
CHEMBL8327 DEMETHYL-CANTHARIDIN IC50 = 960.0 nM 6.02
CHEMBL368311 IC50 = 3200.0 nM 5.50
CHEMBL175630 IC50 = 7000.0 nM 5.16
CHEMBL177853 IC50 = 7700.0 nM 5.11
CHEMBL425851 IC50 = 9200.0 nM 5.04
CHEMBL175996 IC50 = 9200.0 nM 5.04
CHEMBL175576 IC50 = 12000.0 nM 4.92
CHEMBL6951 IC50 = 13000.0 nM 4.89
CHEMBL367750 IC50 = 21000.0 nM 4.68
CHEMBL368606 IC50 > 100000.0 nM -
CHEMBL369464 IC50 > 100000.0 nM -
CHEMBL368167 IC50 > 100000.0 nM -
CHEMBL176328 IC50 > 100000.0 nM -
CHEMBL369584 IC50 > 100000.0 nM -
CHEMBL174701 IC50 > 100000.0 nM -