Assay Detail
Binding
CHEMBL768162
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Inhibitory concentration against protein phosphatase 2A (PP2A) using phosphorylase-a assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (CHEMBL3862) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.93 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421377 | — | — | 1 | 9.52 |
| CHEMBL318253 | — | — | 1 | 6.80 |
| CHEMBL101932 | — | — | 1 | 6.30 |
| CHEMBL97992 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421377 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL318253 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL101932 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL97992 | — | IC50 | = | 7800.0 | nM | 5.11 |