Assay Detail
Binding
CHEMBL768244
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Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C beta C1b domain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.04 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27266 | INDOLACTUM | — | 1 | 6.87 |
| CHEMBL28205 | — | — | 1 | 6.58 |
| CHEMBL318971 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27266 | INDOLACTUM | Ki | = | 135.6 | nM | 6.87 |
| CHEMBL28205 | — | Ki | = | 260.8 | nM | 6.58 |
| CHEMBL318971 | — | Ki | = | 22010.0 | nM | 4.66 |