Assay Detail
Binding
CHEMBL768261
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Inhibition of HIV-1 protease by fluorometric assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.73 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350109 | — | — | 1 | 8.51 |
| CHEMBL150626 | — | — | 1 | 8.47 |
| CHEMBL3350103 | — | — | 1 | 8.14 |
| CHEMBL3350096 | — | — | 1 | 7.96 |
| CHEMBL130998 | — | — | 1 | 7.64 |
| CHEMBL3350106 | — | — | 1 | 7.41 |
| CHEMBL3350098 | — | — | 1 | 7.37 |
| CHEMBL3350099 | — | — | 1 | 7.23 |
| CHEMBL3350101 | — | — | 1 | 7.20 |
| CHEMBL3350113 | — | — | 1 | 7.08 |
| CHEMBL3350100 | — | — | 1 | 7.07 |
| CHEMBL3350114 | — | — | 1 | 7.03 |
| CHEMBL3350094 | — | — | 1 | 6.85 |
| CHEMBL3350102 | — | — | 1 | 6.46 |
| CHEMBL3350104 | — | — | 1 | 6.29 |
| CHEMBL3350095 | — | — | 1 | 6.29 |
| CHEMBL3350110 | — | — | 1 | 6.27 |
| CHEMBL3350111 | — | — | 1 | 6.15 |
| CHEMBL3350090 | — | — | 1 | 6.04 |
| CHEMBL3350097 | — | — | 1 | 5.85 |
| CHEMBL3350091 | — | — | 1 | 5.75 |
| CHEMBL3350108 | — | — | 1 | 5.66 |
| CHEMBL3350105 | — | — | 1 | 5.66 |
| CHEMBL3350107 | — | — | 1 | 5.22 |
| CHEMBL3350112 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350109 | — | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL150626 | — | Ki | = | 3.388 | nM | 8.47 |
| CHEMBL3350103 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL3350096 | — | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL130998 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL3350106 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL3350098 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL3350099 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL3350101 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL3350113 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL3350100 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL3350114 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL3350094 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL3350102 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL3350104 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL3350095 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL3350110 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL3350111 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL3350090 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL3350097 | — | Ki | = | 1412.54 | nM | 5.85 |
| CHEMBL3350091 | — | Ki | = | 1778.28 | nM | 5.75 |
| CHEMBL3350108 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL3350105 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL3350107 | — | Ki | = | 6025.6 | nM | 5.22 |
| CHEMBL3350112 | — | Ki | = | 25118.86 | nM | 4.60 |