Assay Detail
Binding
CHEMBL768319
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Concentration required to inhibit Y181C type RNA dependent DNA polymerase.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.79 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338435 | — | — | 1 | 6.29 |
| CHEMBL151565 | — | — | 1 | 6.10 |
| CHEMBL124338 | — | — | 1 | 5.96 |
| CHEMBL151955 | — | — | 1 | 5.70 |
| CHEMBL151316 | — | — | 1 | 5.70 |
| CHEMBL358754 | — | — | 1 | 5.43 |
| CHEMBL147224 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338435 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL151565 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL124338 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL151955 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL151316 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL358754 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL147224 | — | IC50 | = | 4800.0 | nM | 5.32 |