Assay Detail
Binding
CHEMBL768320
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Concentration required to inhibit wild type RNA dependent DNA polymerase.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.79 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151316 | — | — | 1 | 7.22 |
| CHEMBL358754 | — | — | 1 | 7.05 |
| CHEMBL151955 | — | — | 1 | 7.00 |
| CHEMBL147224 | — | — | 1 | 6.75 |
| CHEMBL338435 | — | — | 1 | 6.41 |
| CHEMBL124338 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151316 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL358754 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL151955 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL147224 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL338435 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL124338 | — | IC50 | = | 500.0 | nM | 6.30 |