Assay Detail
Binding
CHEMBL768322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5B
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.45 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174719 | — | — | 1 | 7.35 |
| CHEMBL362185 | — | — | 1 | 7.00 |
| CHEMBL366823 | — | — | 1 | 6.96 |
| CHEMBL177929 | — | — | 1 | 6.64 |
| CHEMBL175171 | — | — | 1 | 6.46 |
| CHEMBL176543 | — | — | 1 | 5.60 |
| CHEMBL174910 | — | — | 1 | 5.41 |
| CHEMBL179681 | — | — | 1 | 5.35 |
| CHEMBL175011 | — | — | 1 | 5.30 |
| CHEMBL19332 | — | — | 1 | 5.24 |
| CHEMBL177930 | — | — | 1 | 5.17 |
| CHEMBL18927 | — | — | 1 | 5.10 |
| CHEMBL177410 | — | — | 1 | 5.00 |
| CHEMBL366966 | — | — | 1 | 4.96 |
| CHEMBL175533 | — | — | 1 | 4.80 |
| CHEMBL367740 | — | — | 1 | 4.78 |
| CHEMBL426948 | — | — | 1 | 4.60 |
| CHEMBL175095 | — | — | 1 | 4.52 |
| CHEMBL368481 | — | — | 1 | 4.36 |
| CHEMBL174646 | — | — | 1 | 4.33 |
| CHEMBL175364 | — | — | 1 | - |
| CHEMBL177767 | — | — | 1 | - |
| CHEMBL178016 | — | — | 1 | - |
| CHEMBL46789 | — | — | 1 | - |
| CHEMBL177968 | — | — | 1 | - |
| CHEMBL177776 | — | — | 1 | - |
| CHEMBL177429 | — | — | 1 | - |
| CHEMBL177297 | — | — | 1 | - |
| CHEMBL16281 | — | — | 1 | - |
| CHEMBL177529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174719 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL362185 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL366823 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL177929 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL175171 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL176543 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL174910 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL179681 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL175011 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL19332 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL177930 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL18927 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL177410 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL366966 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL175533 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL367740 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL426948 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL175095 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL368481 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL174646 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL175364 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL178016 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL46789 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177968 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177776 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177429 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177297 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL16281 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177529 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL177826 | — | IC50 | > | 50000.0 | nM | - |