Assay Detail
Binding
CHEMBL768365
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Inhibition of protein kinase A (PKA) in bovine heart
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.44 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 6.05 |
| CHEMBL268888 | — | — | 1 | 5.57 |
| CHEMBL6274 | — | — | 1 | 5.34 |
| CHEMBL6279 | — | — | 1 | 5.31 |
| CHEMBL267126 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL268888 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL6274 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL6279 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL267126 | — | IC50 | = | 12100.0 | nM | 4.92 |