Assay Detail
Binding
CHEMBL768367
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Inhibition of cAMP dependent Protein kinase A (PKA) catalytic subunit from bovine heart
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.29 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104264 | — | — | 1 | 6.87 |
| CHEMBL426336 | — | — | 1 | 6.34 |
| CHEMBL263964 | — | — | 1 | 6.17 |
| CHEMBL438544 | — | — | 1 | 6.16 |
| CHEMBL413173 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104264 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL426336 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL263964 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL438544 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL413173 | — | IC50 | = | 1200.0 | nM | 5.92 |