Assay Detail
Binding
CHEMBL768368
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Inhibition of cAMP-dependent Protein kinase A (PKA)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL2654) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.20 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48636 | — | — | 1 | 7.70 |
| CHEMBL91126 | — | — | 1 | 7.30 |
| CHEMBL265559 | — | — | 1 | 7.22 |
| CHEMBL89384 | — | — | 1 | 6.68 |
| CHEMBL91541 | — | — | 1 | 6.60 |
| CHEMBL89639 | — | — | 1 | 6.54 |
| CHEMBL86680 | — | — | 1 | 6.52 |
| CHEMBL89833 | — | — | 1 | 6.50 |
| CHEMBL421539 | — | — | 1 | 6.48 |
| CHEMBL90330 | — | — | 1 | 6.46 |
| CHEMBL312846 | — | — | 1 | 6.46 |
| CHEMBL327994 | — | — | 1 | 6.44 |
| CHEMBL328747 | — | — | 1 | 6.36 |
| CHEMBL88466 | — | — | 1 | 6.36 |
| CHEMBL89591 | — | — | 1 | 6.33 |
| CHEMBL313814 | — | — | 1 | 6.33 |
| CHEMBL89210 | — | — | 1 | 6.33 |
| CHEMBL89280 | — | — | 1 | 6.30 |
| CHEMBL433175 | — | — | 1 | 6.00 |
| CHEMBL88812 | — | — | 1 | 5.92 |
| CHEMBL433361 | — | — | 1 | 5.77 |
| CHEMBL89355 | — | — | 1 | 5.75 |
| CHEMBL88454 | — | — | 1 | 5.72 |
| CHEMBL316088 | — | — | 1 | 5.41 |
| CHEMBL89191 | — | — | 1 | 5.37 |
| CHEMBL313550 | — | — | 1 | 5.17 |
| CHEMBL88848 | — | — | 1 | 5.10 |
| CHEMBL88962 | — | — | 1 | 4.54 |
| CHEMBL329437 | — | — | 1 | - |
| CHEMBL91412 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48636 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL91126 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL265559 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL89384 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL91541 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL89639 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL86680 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL89833 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL421539 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL90330 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL312846 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL327994 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL328747 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL88466 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL89591 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL313814 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL89210 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL89280 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL433175 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL88812 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL433361 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL89355 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL88454 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL316088 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL89191 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL313550 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL88848 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL88962 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL329437 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL91412 | — | IC50 | > | 150000.0 | nM | - |