Assay Detail
Binding
CHEMBL768433
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Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Molecular design of novel PGI2 agonists without PG skeleton. I
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.62 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 7.57 |
| CHEMBL10470 | — | — | 1 | 6.22 |
| CHEMBL10742 | — | — | 1 | 6.19 |
| CHEMBL10442 | — | — | 1 | 5.52 |
| CHEMBL10856 | — | — | 1 | 5.51 |
| CHEMBL10261 | — | — | 1 | 5.41 |
| CHEMBL10564 | — | — | 1 | 5.31 |
| CHEMBL275493 | — | — | 1 | 5.28 |
| CHEMBL10740 | — | — | 1 | 5.11 |
| CHEMBL10439 | — | — | 1 | 5.02 |
| CHEMBL10404 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL10470 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL10742 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL10442 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL10856 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL10261 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL10564 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL275493 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL10740 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL10439 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL10404 | — | IC50 | = | 23000.0 | nM | 4.64 |