Assay Detail
Binding
CHEMBL768434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Molecular design of novel PGI2 agonists without PG skeleton. II
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.29 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 7.57 |
| CHEMBL268477 | AP-227 | — | 1 | 6.82 |
| CHEMBL416334 | — | — | 1 | 6.82 |
| CHEMBL268051 | — | — | 1 | 6.66 |
| CHEMBL11088 | — | — | 1 | 6.42 |
| CHEMBL10470 | — | — | 1 | 6.22 |
| CHEMBL10742 | — | — | 1 | 6.19 |
| CHEMBL495 | ALPROSTADIL | 4.0 | 1 | 5.85 |
| CHEMBL10829 | — | — | 1 | 5.68 |
| CHEMBL418338 | — | — | 1 | 5.66 |
| CHEMBL10853 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL268477 | AP-227 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL416334 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL268051 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL11088 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL10470 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL10742 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL495 | ALPROSTADIL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL10829 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL418338 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL10853 | — | IC50 | = | 5300.0 | nM | 5.28 |