Assay Detail
Binding
CHEMBL768435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular design of novel PGI2 agonists without PG skeleton. IV
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.24 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430154 | — | — | 1 | 8.10 |
| CHEMBL11746 | — | — | 1 | 7.75 |
| CHEMBL11765 | — | — | 1 | 7.40 |
| CHEMBL11480 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430154 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL11746 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL11765 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL11480 | — | IC50 | = | 2000.0 | nM | 5.70 |