Assay Detail
Binding
CHEMBL768446
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In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes
41
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.93 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159876 | — | — | 1 | 5.70 |
| CHEMBL163278 | — | — | 1 | 5.70 |
| CHEMBL350510 | — | — | 1 | 5.70 |
| CHEMBL355596 | — | — | 1 | 5.60 |
| CHEMBL161608 | — | — | 1 | 5.52 |
| CHEMBL159859 | — | — | 3 | 5.47 |
| CHEMBL162406 | — | — | 1 | 5.40 |
| CHEMBL161357 | — | — | 1 | 5.40 |
| CHEMBL159778 | — | — | 1 | 5.30 |
| CHEMBL159851 | — | — | 1 | 5.16 |
| CHEMBL161911 | — | — | 1 | 5.16 |
| CHEMBL159737 | — | — | 1 | 5.10 |
| CHEMBL422719 | — | — | 1 | 5.05 |
| CHEMBL159243 | — | — | 1 | 5.05 |
| CHEMBL445644 | — | — | 2 | 4.92 |
| CHEMBL346590 | — | — | 1 | 4.89 |
| CHEMBL159571 | — | — | 1 | 4.89 |
| CHEMBL159268 | — | — | 1 | 4.85 |
| CHEMBL423248 | — | — | 1 | 4.64 |
| CHEMBL350595 | — | — | 1 | 4.60 |
| CHEMBL352668 | — | — | 2 | 4.55 |
| CHEMBL161304 | — | — | 1 | 4.50 |
| CHEMBL161063 | — | — | 1 | 4.43 |
| CHEMBL435049 | — | — | 1 | 4.40 |
| CHEMBL162032 | — | — | 1 | 4.29 |
| CHEMBL158687 | — | — | 1 | 4.22 |
| CHEMBL159344 | — | — | 1 | 4.14 |
| CHEMBL159196 | — | — | 1 | 4.12 |
| CHEMBL353356 | — | — | 1 | - |
| CHEMBL161104 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163278 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL350510 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL159876 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL355596 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL161608 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL159859 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL162406 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL161357 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL159859 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL159778 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL159851 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL161911 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL159737 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL422719 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL159243 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL445644 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL159571 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL346590 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL159268 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL423248 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL350595 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL352668 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL161304 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL352668 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL161063 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL435049 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL445644 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL162032 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL158687 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL159344 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL159196 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL159699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL159859 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL348968 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL350816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | > | 100000.0 | nM | - |
| CHEMBL352196 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL161518 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL353356 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL161104 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL352075 | — | IC50 | > | 100000.0 | nM | - |