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Assay Detail

CHEMBL768534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory effect on protein kinase C using histone II-As as substrate
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2093867)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and biological activities of NB-506 analogues modified at the glucose group.
Ohkubo M, Nishimura T, Kawamoto H, Nakano M, Honma T, Yoshinari T, Arakawa H, Suda H, Morishima H, Nishimura S.
Bioorg Med Chem Lett (2000) 10 : 419 -422
PubMed 10743939 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.66 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL334337 1 5.52
CHEMBL334360 1 4.92
CHEMBL338966 1 4.77
CHEMBL135492 1 4.70
CHEMBL406901 1 4.70
CHEMBL135970 1 4.68
CHEMBL434237 1 4.64
CHEMBL335940 1 4.30
CHEMBL134536 1 4.22
CHEMBL334869 1 4.14
CHEMBL132533 1 -
CHEMBL433855 1 -
CHEMBL133209 1 -
CHEMBL135491 1 -
CHEMBL338967 1 -
CHEMBL435191 EDOTECARIN 3.0 1 -
CHEMBL135881 1 -
CHEMBL2029060 1 -
CHEMBL336626 1 -
CHEMBL334461 1 -
CHEMBL405405 1 -
CHEMBL336603 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL334337 IC50 = 3000.0 nM 5.52
CHEMBL334360 IC50 = 12000.0 nM 4.92
CHEMBL338966 IC50 = 17000.0 nM 4.77
CHEMBL135492 IC50 = 20000.0 nM 4.70
CHEMBL406901 IC50 = 20000.0 nM 4.70
CHEMBL135970 IC50 = 21000.0 nM 4.68
CHEMBL434237 IC50 = 23000.0 nM 4.64
CHEMBL335940 IC50 = 50000.0 nM 4.30
CHEMBL134536 IC50 = 60000.0 nM 4.22
CHEMBL334869 IC50 = 72000.0 nM 4.14
CHEMBL132533 IC50 = 120000.0 nM -
CHEMBL433855 IC50 > 200000.0 nM -
CHEMBL133209 IC50 > 200000.0 nM -
CHEMBL135491 IC50 > 200000.0 nM -
CHEMBL338967 IC50 > 200000.0 nM -
CHEMBL435191 EDOTECARIN IC50 = 200000.0 nM -
CHEMBL135881 IC50 > 200000.0 nM -
CHEMBL2029060 IC50 > 200000.0 nM -
CHEMBL336626 IC50 > 200000.0 nM -
CHEMBL334461 IC50 = 150000.0 nM -
CHEMBL405405 IC50 = 130000.0 nM -
CHEMBL336603 IC50 > 200000.0 nM -