Assay Detail
Binding
CHEMBL768536
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Inhibition of protein kinase C (PKC)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.03 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113185 | — | — | 1 | 6.82 |
| CHEMBL322066 | — | — | 1 | 5.89 |
| CHEMBL112263 | — | — | 1 | 5.85 |
| CHEMBL112346 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113185 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL322066 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL112263 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL112346 | — | IC50 | = | 2874.0 | nM | 5.54 |