Assay Detail
Binding
CHEMBL768609
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Inhibitory concentration against phosphodiesterase 4.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Comparative molecular field analysis (CoMFA) of phthalazine derivatives as phosphodiesterase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.39 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84350 | — | — | 1 | 8.70 |
| CHEMBL79902 | — | — | 1 | 8.40 |
| CHEMBL74404 | — | — | 1 | 8.00 |
| CHEMBL450274 | — | — | 1 | 7.92 |
| CHEMBL79471 | — | — | 1 | 7.85 |
| CHEMBL309341 | — | — | 1 | 7.72 |
| CHEMBL79661 | — | — | 1 | 7.68 |
| CHEMBL82882 | — | — | 1 | 7.60 |
| CHEMBL311025 | — | — | 1 | 7.55 |
| CHEMBL308407 | — | — | 1 | 7.52 |
| CHEMBL83872 | — | — | 1 | 7.52 |
| CHEMBL419814 | — | — | 1 | 7.52 |
| CHEMBL421343 | — | — | 1 | 7.52 |
| CHEMBL82934 | — | — | 1 | 7.44 |
| CHEMBL310387 | — | — | 1 | 7.43 |
| CHEMBL79535 | — | — | 1 | 7.42 |
| CHEMBL308158 | — | — | 1 | 7.41 |
| CHEMBL72362 | — | — | 1 | 7.38 |
| CHEMBL80107 | — | — | 1 | 7.32 |
| CHEMBL84115 | — | — | 1 | 7.29 |
| CHEMBL70391 | — | — | 1 | 7.28 |
| CHEMBL74631 | — | — | 1 | 7.25 |
| CHEMBL70903 | — | — | 1 | 7.23 |
| CHEMBL79739 | — | — | 1 | 7.14 |
| CHEMBL310612 | — | — | 1 | 7.12 |
| CHEMBL309420 | — | — | 1 | 7.07 |
| CHEMBL312375 | — | — | 1 | 7.03 |
| CHEMBL81226 | — | — | 1 | 6.95 |
| CHEMBL421151 | — | — | 1 | 6.88 |
| CHEMBL312322 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84350 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL79902 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL74404 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL450274 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL79471 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL309341 | — | IC50 | = | 19.05 | nM | 7.72 |
| CHEMBL79661 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL82882 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL311025 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL308407 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL83872 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL419814 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL421343 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL82934 | — | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL310387 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL79535 | — | IC50 | = | 38.02 | nM | 7.42 |
| CHEMBL308158 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL72362 | — | IC50 | = | 41.69 | nM | 7.38 |
| CHEMBL80107 | — | IC50 | = | 47.86 | nM | 7.32 |
| CHEMBL84115 | — | IC50 | = | 51.29 | nM | 7.29 |
| CHEMBL70391 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL74631 | — | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL70903 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL79739 | — | IC50 | = | 72.44 | nM | 7.14 |
| CHEMBL310612 | — | IC50 | = | 75.86 | nM | 7.12 |
| CHEMBL309420 | — | IC50 | = | 85.11 | nM | 7.07 |
| CHEMBL312375 | — | IC50 | = | 93.33 | nM | 7.03 |
| CHEMBL81226 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL421151 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL312322 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL81020 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL79744 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL303880 | — | IC50 | = | 186.21 | nM | 6.73 |
| CHEMBL81364 | — | IC50 | = | 239.88 | nM | 6.62 |