Assay Detail
Binding
CHEMBL768682
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Inhibition of Prostaglandin G/H synthase 2 was measured by the inhibition of PGE-2 produced by lipopolysaccharide-challenged HWB
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.74 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 7.22 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL94938 | — | — | 1 | 6.05 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 5.96 |
| CHEMBL96098 | — | — | 1 | 5.77 |
| CHEMBL92759 | — | — | 1 | 5.75 |
| CHEMBL95156 | — | — | 1 | 5.75 |
| CHEMBL329120 | — | — | 1 | 5.68 |
| CHEMBL420628 | — | — | 1 | 5.62 |
| CHEMBL96950 | — | — | 1 | 5.58 |
| CHEMBL92233 | — | — | 1 | 5.57 |
| CHEMBL96947 | — | — | 1 | 5.42 |
| CHEMBL94939 | — | — | 1 | 5.24 |
| CHEMBL92793 | — | — | 1 | 5.16 |
| CHEMBL96842 | — | — | 1 | 5.10 |
| CHEMBL329419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL94938 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL96098 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL92759 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL95156 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL329120 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL420628 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL96950 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL92233 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL96947 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL94939 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL92793 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL96842 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL329419 | — | IC50 | > | 33000.0 | nM | - |