Assay Detail
Binding
CHEMBL768683
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Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.46 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361563 | — | — | 1 | 7.30 |
| CHEMBL274990 | SC-58125 | — | 1 | 7.05 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361563 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL274990 | SC-58125 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 9400.0 | nM | 5.03 |