Assay Detail
Binding
CHEMBL768689
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Binding affinity for Potassium channel HERG Kv11.1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.00 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084953 | — | — | 1 | 5.72 |
| CHEMBL25211 | — | — | 1 | 5.55 |
| CHEMBL23979 | — | — | 1 | 5.24 |
| CHEMBL22359 | — | — | 1 | 5.23 |
| CHEMBL3084944 | — | — | 1 | 4.77 |
| CHEMBL3084949 | — | — | 1 | 4.66 |
| CHEMBL25437 | — | — | 1 | 4.46 |
| CHEMBL22679 | — | — | 1 | 4.40 |
| CHEMBL3084938 | — | — | 1 | - |
| CHEMBL497992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084953 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL25211 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL23979 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL22359 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL3084944 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL3084949 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL25437 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL22679 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL3084938 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL497992 | — | Ki | > | 100000.0 | nM | - |