Assay Detail
Binding
CHEMBL768861
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Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.26 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156140 | — | — | 1 | 8.89 |
| CHEMBL351567 | — | — | 1 | 8.60 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.59 |
| CHEMBL345917 | — | — | 1 | 8.49 |
| CHEMBL351568 | — | — | 1 | 6.75 |
| CHEMBL156328 | — | — | 1 | - |
| CHEMBL88990 | NITRAQUAZONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156140 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL351567 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL345917 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL351568 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL156328 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL88990 | NITRAQUAZONE | IC50 | = | 14.0 | nM | - |