Assay Detail
Binding
CHEMBL768957
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Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.38 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112567 | — | — | 1 | 8.46 |
| CHEMBL332028 | — | — | 1 | 7.82 |
| CHEMBL419947 | — | — | 1 | 7.52 |
| CHEMBL117911 | — | — | 1 | 7.46 |
| CHEMBL332937 | — | — | 1 | 7.42 |
| CHEMBL119720 | — | — | 1 | 7.35 |
| CHEMBL118839 | — | — | 1 | 7.16 |
| CHEMBL13878 | TEBUFELONE | 2.0 | 1 | 7.00 |
| CHEMBL421608 | — | — | 1 | 6.70 |
| CHEMBL119472 | — | — | 1 | 6.66 |
| CHEMBL119418 | — | — | 1 | 6.60 |
| CHEMBL119170 | — | — | 1 | 6.26 |
| CHEMBL122065 | — | — | 1 | 6.02 |
| CHEMBL119433 | — | — | 1 | 6.00 |
| CHEMBL326362 | — | — | 1 | 5.52 |
| CHEMBL326365 | — | — | 1 | 5.46 |
| CHEMBL331749 | — | — | 1 | 5.40 |
| CHEMBL119618 | — | — | 1 | 5.40 |
| CHEMBL117615 | — | — | 1 | 5.35 |
| CHEMBL118335 | — | — | 1 | 5.22 |
| CHEMBL117682 | — | — | 1 | 5.05 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.52 |
| CHEMBL422075 | — | — | 1 | - |
| CHEMBL274893 | SC-57666 | — | 1 | - |
| CHEMBL326295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112567 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL332028 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL419947 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL117911 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL332937 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL119720 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL118839 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL13878 | TEBUFELONE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL421608 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL119472 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL119418 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL119170 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL122065 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL119433 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL326362 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL326365 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL331749 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL119618 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL117615 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL118335 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL117682 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL422075 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274893 | SC-57666 | IC50 | < | 300.0 | nM | - |
| CHEMBL326295 | — | IC50 | > | 100000.0 | nM | - |