Assay Detail
Binding
CHEMBL768960
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Inhibitory activity against human recombinant Prostaglandin G/H synthase 2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,4-diarylthiophenes are selective COX-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.49 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316823 | — | — | 1 | 8.10 |
| CHEMBL97874 | — | — | 1 | 8.05 |
| CHEMBL42485 | DUP-697 | — | 1 | 7.85 |
| CHEMBL328837 | — | — | 1 | 7.82 |
| CHEMBL100422 | — | — | 1 | 7.52 |
| CHEMBL98903 | — | — | 1 | 7.30 |
| CHEMBL319306 | — | — | 1 | 7.10 |
| CHEMBL319072 | — | — | 1 | 6.16 |
| CHEMBL97935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316823 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL97874 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL42485 | DUP-697 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL328837 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL100422 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL98903 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL319306 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL319072 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL97935 | — | IC50 | > | 100000.0 | nM | - |